Peptide Modifications
- Click Chemistry
- including azido-containing and alkyne-containing components. We also offer Huisgen 1,3-dipolar cycloaddition,1 in particular the Cu(I)-catalyzed variant.
- 15N & 13C Isotope labeled peptides
- non-radioactive isotope labeling
- Dye labeled peptides
- full range of dyes available, yellow, green, purple, red, etc.
- PEGylation
- covalent conjugation of polyethylene glycols (PEG) to peptides. Low to high MW options, conjugated to N-terminus, C-terminus, and AA side chains.
- Fluorescent peptides
- important tools in biochemical and biological research to study interactions between proteins, to analyze conformational structures.
- Phospho peptides (phosphorylated)
- Ser, Thr, and Tyr phosphorylation sites available.
- 15N & 13C Isotope labeled peptides
- biotinylation via either the sulfhydryl (SH) group, or amino group (NH2), with or without a spacer (Ahx).
- Fatty Acid labeled peptides
- Palmitoyl, myristoyl, capryl, carnosine, octyl, octyl-carnonine, carnosine-octylester, etc.
- Disulfide Bond containing peptides
- Important structure motifs, achieved by the oxidation of thiol groups to form disulfide bonds.
- FRET Pairing
- Modification Spotlight: FRET Pairing info (Fluorescence Resonance Energy Transfer).
Modifications
We provide the most comprehensive range of peptide modifications available, including common additions such as:
| Modification | |
| Acetylation (N-Terminal) | |
| Acetylation (Lys) | |
| Formylation (N-Terminal) | |
| Fatty acid (N-Terminal) | |
| Myristic acid (N-Terminal) | |
| Palmitoyl/Palmitic Acid (N-Terminal) |
|
| Cys(Acm), Cys(tBu) | |
| Benzyloxycarbonylation (CBZ) | |
| Amidation (C-Terminal) | |
| p-Nitroanilide (pNA, C-Terminal) | |
| AMC ( C-Terminal) | |
| Succinylation (Suc, N-Terminal) | |
| NHS (OSu, C-Terminal) | |
| PEG conjugation (Pegylation), low and high MW | |
| Special amino acid | |
| D-Ile，Gamma-Glu, beta-Asp | |
| D-Arg, D-Cys, D-Asp, D-Asn, D-Glu, D-Gln, D-Ser, D-His, D-Thr, D-Trp, D-Lys, D-Tyr, D-Orn, Orn, Abu, Aib, (D)1-Nal, (D)2-Pal, (D)4-Cl-Phe, Nva, Nle, Hse, Hcy, Pen, Mpa | |
| N-Methyl amino acid (Ala, Phe, Leu, Ile, Val, Gly, Met) |
|
| D-Ala, D-Leu, D-Met, D-Pro, D-Val, D-Phe, -Ala, pGlu, Hyp |
|
| Dinitrobenzoylation (Lys) | |
| Lys(Me2) | |
| Phosphorylation (Tyr, Ser, Thr, single site) |
|
| Tyr(SO3H2) | |
| Ser(octanoic acid) | |
| Isotope Amino acid | |
| Stable label amino acid (N15, C13) | |
| Fluorescence/Dye Labeling | |
| Biotin (N-Terminal, Y/N Ahx) | |
| Biotin (Lys in sequence) | |
| Biotin (without Lys in sequence) | |
| FITC/5-FAM (N-Terminal, Y/N Ahx) | |
| Dansyl (N-Terminal, Y/N Ahx) | |
| MCA (N-Terminal) | |
| HYNIC (N-Terminal) | |
| DTPA (N-Terminal) | |
| Cyclic peptide | |
| Disulfide bridge 1st | |
| Disulfide bridge 2nd | |
| Disulfide bridge 3rd | |
| Amide cyclic (Side chain, end) | |
| Quenched fluorescent peptide | |
| Abz/ Tyr (3-NO2) | |
| EDANS or DABCYL | |
| MultipleAntigenicPeptide System | |
| Asymmetric 4 branches | |
| Asymmetric 8 branches | |
| Crude peptide w/ HPLC analysis | |
| KLH | |
| BSA | |
| Aliquoting | |
| Amino Acid Analysis (AAA) by Nitrogen |
|