Peptide Phage Display – How is it Beneficial in Drug Discovery?

DATE: October 1, 2014

Protein and peptide formation through synthesis has been imperative in various kinds of studies and throughput discoveries. Phage display in peptides is a molecular technique created to study different kinds of protein combination or formation, such as protein-protein, protein-peptide, and other interactions. The tool has been widely used in various kinds of protein engineering methods as well as drug discovery.

Here’s how the process starts:

The gene is encoded with the protein of interest and is then inserted into a phage that links the genetic information with the protein’s function. This makes the phage display protein on the outside and gene from inside, thereby creating a link between genotype and phenotype. The displaying phage is compared with other DNA sequences, proteins, and peptides to determine the interaction habit between molecules and the displayed protein phage.

Using the procedure above, various peptide library designs can be screened.

How it helps in drug discoveries?

The process helps in determining the interaction pattern of the proteins and their functions. The in vitro protein evolution method helps in finding new ligands to target proteins. Phage display for antibodies are often used to isolate other therapeutic antibody leads that can be later used for the development into antibody drugs.

Proven applications in the past:

The MRC Laboratory of Molecular Biology displayed the invention of antibody phage display in 1991. The institute was the first to report the display and selection of human antibodies.

A peptide synthesis company generally offers these synthesis services at a highly cost-effective price. Peptide library services have been one of the most sought after ways for all kinds of drugs discoveries, vaccine development, and for studying immune responses as well. The immense benefits of the peptide drugs have increased the demand for peptide libraries among pharmaceutical companies. There are various providers available online from where you can obtain the peptide library and use if for all kinds of research and development purposes.

About The Author:

We synthesize virtually every antimicrobial peptide (AMP), such as LL-37, for Host Defense Peptide studies. Contact us today for pricing on your specific AMP of interest.