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CAS: 53-84-9

B-Nicotinamide adenine dinucleotide

β-Nicotinamide adenine dinucleotide (NAD⁺) plays a major role in metabolism as a cofactor and mobile electron acceptor. NAD⁺ is a required oxidizing cosubstrate for many enzymes. It is reduced to NADH which carries electrons to the electron transport chain for subsequent oxidative phosphorylation and ATP production. NAD⁺ is capable of donating ADP-ribose moieties to a protein, producing nicotinamide in the process. Sirtuin enzymes use NAD⁺ as a substrate to deacetylate proteins and direct activity between the nucleus and mitochondria. NAD⁺ is regenerated by fermentation and by oxidative phosphorylation.